Benzamide,4-[3-[[(2R)-2-hydroxy-2-phenylethyl]amino]-3-methylbutyl]-, monohydrochloride(9CI)

Uses

LY-195448 hydrochloride is a phenethanolamine that exhibits anti-tumour activity across various murine tumour models. LY-195448 hydrochloride acts by blocking cells at metaphase. LY-195448 hydrochloride has demonstrated a lack of "standard" side effects commonly associated with cancer treatments, such as myelosuppression and gastrointestinal toxicity. LY-195448 hydrochloride was evaluated in a phase I trial, where it showed only mild and reversible side effects like hypotension, tachycardia, and tremor.

References

[1] Phase I clinical and pharmacokinetic study of LY 195448