3-Hydroxybutanoic acid magnesium salt

Uses

3-Hydroxybutyric acid magnesium salt is a natural metabolite formed during fat digestion and metabolism, and is called ketone body. Just as glucose is an energy molecule derived from carbohydrates / sugars, while amino acids are derived from proteins, ketones are energy molecules derived from fats.
Magnesium 3-hydroxybutyrate is an energy-intensive molecule that naturally provides energy to your brain, heart and muscles during low carbohydrate intake.
Magnesium 3-hydroxybutyrate is a dietary supplement ingredient and is generally recognized as safe food (GRAS).

Synthesis

In 500ml there-necked flask, (the R)-ethyl 3-hydroxybutanoate (86.9g) obtained in embodiment 2 is added, is added 300ml water, is slowly added into sodium hydroxide (26.5g) in batches in 2 hours, control temperature is not higher than 10 DEG C, adds continuation reaction 3 small When, reaction solution crosses 732 cationic ion-exchange resins, obtains (R) -3-hydroxybutyrate aqueous solution, is concentrated into 200g/L, in 5 hours in batches Magnesium hydroxide (19.2g) is slowly added into, continuation is added and reacts 5 hours, add 0.3g activated carbons, continues to stir 0.5 hour, mistake Filter, filtrate is concentrated into 100ml, now has a large amount of solids to separate out, is down to and crystallization is stirred at room temperature 1 hour, centrifuges, and vacuum drying is obtained White solid R-3- hydroxybutyric acid magnesium 64.5g, yield 85.0%, ee values are 91.6%.