![INT-767 Structure](https://www.chemicalbook.com/CAS/20211123/GIF/1000403-03-1.gif)
INT-767
- Product NameINT-767
- CAS1000403-03-1
- CBNumberCB33048660
- MFC25H45NaO6S
- MW496.68
- MOL File1000403-03-1.mol
Chemical Properties
storage temp. | Store at -20°C |
solubility | DMSO : ≥ 205.5 mg/mL (415.44 mM) |
INT-767 Chemical Properties,Usage,Production
Description
INT-767 is a G-protein coupled/Farnesoid X-activated receptor agonist potentially for the treatment of hepatic fibrosis. INT-767 significantly improved serum liver enzymes, hepatic inflammation, and biliary fibrosis in Mdr2(-/-) mice. INT-767 significantly induced bile flow and biliary HCO?3- output, as well as gene expression of carbonic anhydrase 14, an important enzyme able to enhance HCO?3- transport, in an Fxr-dependent manner. In addition, INT-767 dramatically reduced bile acid synthesis via the induction of ileal Fgf15 and hepatic Shp gene expression, thus resulting in significantly reduced biliary bile acid output in Mdr2(-/-) mice.Preparation Products And Raw materials
INT-767 Suppliers
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