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5,5-DIMETHYL-1-PYRROLINE N-OXIDE

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Structure
5,5-DIMETHYL-1-PYRROLINE N-OXIDE
  • CAS No.3317-61-1
  • Chemical Name:5,5-DIMETHYL-1-PYRROLINE N-OXIDE
  • CBNumber:CB3290637
  • Molecular Formula:C6H11NO
  • Formula Weight:113.16
  • MOL File:3317-61-1.mol
5,5-DIMETHYL-1-PYRROLINE N-OXIDE Property
  • Melting point: :25-29 °C(lit.)
  • Boiling point: :75 °C0.4 mm Hg(lit.)
  • Density  :1.015 g/mL at 25 °C(lit.)
  • refractive index  :n20/D 1.496(lit.)
  • Flash point: :204 °F
  • storage temp.  :−20°C
  • form  :Pale yellow solid or oil.
  • pka :2.47±0.40(Predicted)
  • Merck  :14,3393
  • BRN  :107603
  • Stability: :Stable, but light sensitive, hygroscopic and heat sensitive. Store in the dark, under an inert gas, and keep cold. Incompatible with strong oxidizing agents, moisture.
  • InChIKey :VCUVETGKTILCLC-UHFFFAOYSA-N
  • CAS DataBase Reference :3317-61-1(CAS DataBase Reference)
  • FDA UNII :7170JZ1QF3
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • F  :8-10
  • HazardClass  :IRRITANT
  • HS Code  :29339900
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
5,5-DIMETHYL-1-PYRROLINE N-OXIDE Price More Price(8)
  • Brand: Sigma-Aldrich
  • Product number: 92688
  • Product name : 5,5-Dimethyl-1-pyrroline N-oxide
  • Purity: for ESR-spectroscopy
  • Packaging: 100mg
  • Price: $112
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: D5766
  • Product name : 5,5-Dimethyl-1-pyrroline N-oxide
  • Purity: ≥97%
  • Packaging: 1g
  • Price: $373
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D2362
  • Product name : 5,5-Dimethyl-1-pyrroline N-Oxide
  • Purity: >97.0%(GC)(T)
  • Packaging: 1g
  • Price: $99
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D2362
  • Product name : 5,5-Dimethyl-1-pyrroline N-Oxide
  • Purity: >97.0%(GC)(T)
  • Packaging: 5g
  • Price: $386
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 10006436
  • Product name : DMPO
  • Purity: ≥98%
  • Packaging: 500mg
  • Price: $49
  • Updated: 2021/03/22
  • Buy: Buy

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Chemical Properties,Usage,Production

  • Chemical Properties white to faintly yellow solid
  • Uses Spin trap agent for biological systems.
  • Preparation To a three-necked round bottom flask equipped with a condenser, addi­tion funnel, thermometer, and mechanical stirrer and containing 300 ml. 95% ethanol precooled to 2°C is added, all at once, 14.5 g (0.1 mole) 4-methyl-4-nitropentanol, and 13.1 g (1.2 mole) zinc dust. With rapid agita­tion, the glacial acetic acid (24.0 g, 0.4 mole) is added dropwise over a 1-hr period while maintaining the reaction temperature below 15°C. The mix­ture is stirred vigorously for 2 hr and then stored in the refrigerator for 2 days, at approximately 1°C. Then the zinc acetate is filtered and rinsed with 100 ml of ethanol. The combined ethanol factions are rotoevapo-rated to give the crude nitrone. The crude nitrone is dissolved in a 200 ml portion of dichloromethane and the latter washed two times with saturated sodium bicarbonate solution. The organic layer is dried over sodium sul­fate and the solvent rotoevaporated, to give 10.7 (94% yield) of the crude nitrone. The product was purified by double distillation (b.p. 53°C, 0.1 Torr), to give 6.8 g (60%) of the pure nitrone as a white hygroscopic solid. The H1 NMR (400 MH CDC13, Me4Si) is 6.80 (t, 2H, methylene bound to quaternary C, J = 7.2Hg), 1.43 (s, 6H, methyl), C13NMr (100 MH2, CDC13, Me4 Si) 5=132.4 (Vinyl), 73.5 (quaternary), 34.1 (Allyl), 25.3 (methylene bound to quaternary C), 24.4 (methyls).
    Preparation of 5,5-dimethyl-l-pyrroline-N-oxide
  • Biological Activity Water soluble nitric oxide spin trap; allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). Has a high reaction rate constant for superoxide and hydroxyl radicals, and distinguishes simultaneously among a variety of important biologically generated free radicals.
5,5-DIMETHYL-1-PYRROLINE N-OXIDE Preparation Products And Raw materials
Raw materials
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3317-61-1, 5,5-DIMETHYL-1-PYRROLINE N-OXIDERelated Search:
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  • 5,5-Dimethyl-1-pyrrolineN-Oxide&gt
  • Dimethyl N
  • 3317-61-1
  • Enzymes, Inhibitors, and Substrates
  • Pyrrolines
  • Nitric Oxide Metabolism
  • Nitric Oxide Scavengers
  • ESR Spectrometry
  • Spin Trapping Reagents
  • Building Blocks
  • Biochemicals and Reagents
  • Application Index
  • BioChemical
  • Cell Signaling Enzymes
  • Heterocyclic Building Blocks
  • pharmacetical
  • Analytical Chemistry
  • ESR Spectrometry
  • Spin Trapping Reagents