SB-216641A (0.6-20 mg/kg; i.p.; single dose) hinders the SKF-99101H induced hypothermia with dose-dependent manner in guinea pigs[1].
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2].
| Animal Model: | Guinea pigs[1]. |
| Dosage: | 0.6, 2.0, 6.0 and 20.0 mg/kg. |
| Administration: | Intraperitoneal injection; single dose. |
| Result: | Significantly blocked the effects of SKF-99101H. |
| Animal Model: | Dogs[2]. |
| Dosage: | 559 nmol/kg. |
| Administration: | Intravenous injection; single dose. |
| Result: | Improved the gastric relaxation. |