3,8-Diazabicyclo[3.2.1]octane dihydrochloride

Uses

3,8-diazabicyclo[3.2.1]octane dihydrochloride can be used as a pharmaceutical synthesis intermediate and can be used in laboratory research and development processes.

Synthesis

An anhydrous ethanol solution of 3-benzyl-3,8-diazabicyclo[3.2.1]octane (1.31 g, 6.5 mmol) was hydrogenated in that presence (55 mL) and 6NHCl (3 mL) was added to a 10% palladium carbon (0.3 g, 0.3 mmol) device in Parr and held at room temperature and 3 atmospheres for 12 hours. This was filtered off the catalyst and ethanol pressure was removed under reduced pressure. The residue was dissolved in Et2O and ethanol was added dropwise until a precipitate was formed. The precipitate was collected to give 1 g of 3,8-diazabicyclo[3.2.1]octane dihydrochloride (83%) as a white solid.