Pharmacology and mechanism of action Indications Side effects Preparations References
ChemicalBook > CAS DataBase List > PYRVINIUM PAMOATE

PYRVINIUM PAMOATE

Pharmacology and mechanism of action Indications Side effects Preparations References
PYRVINIUM PAMOATE Structure
PYRVINIUM PAMOATE
  • CAS No.3546-41-6
  • Chemical Name:PYRVINIUM PAMOATE
  • CBNumber:CB3249600
  • Molecular Formula:C75H70N6O6
  • Formula Weight:1151.39
  • MOL File:3546-41-6.mol
PYRVINIUM PAMOATE Property
  • Melting point: :210-215° (softens at 190°)
  • Boiling point: :829.27°C (rough estimate)
  • Density  :1.0104 (rough estimate)
  • refractive index  :1.6400 (estimate)
  • storage temp.  :2-8°C
  • solubility  :DMSO: >10mg/mL
  • form  :powder
  • color  :red
  • FDA UNII :310X6S84LW
  • NCI Drug Dictionary :pyrvinium pamoate
  • ATC code :P02CX01
  • EPA Substance Registry System :Pyrvinium pamoate (3546-41-6)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H312+H332-H315-H319-H335-H351-H302-H312-H332
  • Precautionary statements P261-P280-P301+P312+P330-P305+P351+P338
PYRVINIUM PAMOATE Price More Price(3)
  • Brand: Sigma-Aldrich
  • Product number: P0027
  • Product name : Pyrvinium pamoate salt hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 10mg
  • Price: $118
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1592001
  • Product name : Pyrvinium pamoate
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 500mg
  • Price: $366
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: P0027
  • Product name : Pyrvinium pamoate salt hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 50mg
  • Price: $467
  • Updated: 2021/03/22
  • Buy: Buy

PYRVINIUM PAMOATE Chemical Properties,Usage,Production

  • Pharmacology and mechanism of action Pyrvinium is a quaternary ammonium derivative of a cyanine dye with marked effect against Enterobius vermicularis.
    The mechanism of action is not well known. The drug inhibits oxidative metabolism in the worms and interferes with the absorption of glucose in intestinal helminths. Since most intestinal worms are dependent on anaerobic carbohydrate metabolism, this may be an important action of the drug[1].
     
  • Indications Infections caused by Enterobius vermicularis. Pyrvinium is largely replaced today by more effective and safer drugs such as albendazole and mebendazole.
     
  • Side effects Gastrointestinal disturbances such as nausea, vomiting, dyspepsia, indigestion and abdominal pain are frequent. Allergic reactions and photosensitivity have been reported. Pyrvinium stains the stool bright red and may stain clothing if vomiting occurs. Patients should be informed about this.
     
  • Preparations Pyrvinium pamoate (embonate): 450 mg of the pamoate is equivalent to 300 mg of pyrvinium.
    • Povanyl ® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tablets 50 mg pyrvinium.
    • Vanquin® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tab pyrvinium.
  • References 1. Buchanan RA, Barrow WB, Heffelfinger JC, Kinkel AW, Smith TC, Turner JL (1974). Pyrvinium pamoate. Clin Pharmacol Ther, 16, 716–719.
  • Uses anthelmintic
  • brand name Povan (Parke-Davis).
  • General Description Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.
  • Air & Water Reactions Insoluble in water.
  • Reactivity Profile PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .
  • Fire Hazard Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.
PYRVINIUM PAMOATE Preparation Products And Raw materials
Raw materials
Preparation Products
Global(69)Suppliers
  • Supplier:
    career henan chemical co
  • Tel:+86-371-86658258
  • Fax:
  • Email:sales@coreychem.com
  • Country:CHINA
  • ProdList:29954
  • Advantage:58
  • Supplier:
    Klong Industrial Co., Ltd
  • Tel:0086-519-68231162
  • Fax:
  • Email:info@klongchem.com
  • Country:CHINA
  • ProdList:131
  • Advantage:58
  • Supplier:
    Chongqing Chemdad Co., Ltd
  • Tel:+86-13650506873
  • Fax:
  • Email:sales@chemdad.com
  • Country:CHINA
  • ProdList:37282
  • Advantage:58
  • Supplier:
    Target Molecule Corp
  • Tel:18019718960 781-999-5354
  • Fax:
  • Email:marketing@targetmol.com
  • Country:United States
  • ProdList:19232
  • Advantage:58
  • Supplier:
    AFINE CHEMICALS LIMITED
  • Tel:008657185134551
  • Fax:008657185134895
  • Email:info@afinechem.com
  • Country:CHINA
  • ProdList:15559
  • Advantage:58
3546-41-6, PYRVINIUM PAMOATERelated Search:
  • 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-quinoliniu
  • alnoxin
  • altolat
  • methyl-,saltwith4,4’-methylenebis(3-hydroxy-2-naphthoicacid)(2:1)
  • molevac
  • neo-oxypate
  • pamovin
  • pirviniumpamoate
  • povan
  • povanyl
  • pyrcon
  • pyrvinium4,4’-methylenebis(3-hydroxynaphthalene-2-carboxylate)
  • pyrviniumembonate
  • sn-4395
  • tolapin
  • tru
  • vanquin
  • vipryniumembonate
  • PYRVINIUM PAMOATE
  • bis(6-dimethylamino-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-methylquinolinium) 3,3-dihydroxy-4,4-methylenedi-2-naphthoate
  • PYRVINIUM PAMOATE 95%
  • Pyrvinium
  • PYRVINIUMPAMOATE,USP
  • PyrviniumChloride
  • 6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)-quinolinium
  • Pyrvinium pamoate salt hydrate
  • Vermitibier
  • Vipyrvinium embonate
  • 6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
  • 6-Dimethylamino-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
  • Poquil
  • Neooxypaat
  • Nsc223622
  • Pyrvinium Pamoate (500 mg)
  • PYRVINIUM PAMOATE USP/EP/BP
  • 3546-41-6
  • 3456-41-6
  • C75H70N6O6
  • POVAN