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3-Bromopropyne

Uses
3-Bromopropyne Structure
3-Bromopropyne
  • CAS No.106-96-7
  • Chemical Name:3-Bromopropyne
  • CBNumber:CB3162370
  • Molecular Formula:C3H3Br
  • Formula Weight:118.96
  • MOL File:106-96-7.mol
3-Bromopropyne Property
  • Melting point: :-61°C
  • Boiling point: :97 °C
  • Density  :1.38 g/mL at 20 °C
  • refractive index  :n20/D 1.494
  • Flash point: :65 °F
  • storage temp.  :Refrigerator
  • form  :Liquid
  • color  :Colorless - Yellow
  • Water Solubility  :Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.
  • Sensitive  :Light Sensitive
  • BRN  :605309
  • InChIKey :YORCIIVHUBAYBQ-UHFFFAOYSA-N
  • CAS DataBase Reference :106-96-7(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :F3H7ZXK9ZU
  • NIST Chemistry Reference :1-Propyne, 3-bromo-(106-96-7)
  • EPA Substance Registry System :Propargyl bromide (106-96-7)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H301-H304-H315-H319-H335-H373-H336-H361d-H314-H318-H333-H361
  • Precautionary statements P210-P260-P301+P310-P370+P378-P403+P235-P280-P261-P281-P305+P351+P338-P331-P301+P310a-P303+P361+P353-P405-P501a
3-Bromopropyne Price More Price(19)
  • Brand: Sigma-Aldrich
  • Product number: 530409
  • Product name : Propargyl bromide solution
  • Purity: 80 wt. % in xylene
  • Packaging: 50g
  • Price: $83.5
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 530409
  • Product name : Propargyl bromide solution
  • Purity: 80 wt. % in xylene
  • Packaging: 125g
  • Price: $182
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0484
  • Product name : Propargyl Bromide (stabilized with MgO)
  • Purity: >97.0%(GC)
  • Packaging: 25g
  • Price: $44
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0484
  • Product name : Propargyl Bromide (stabilized with MgO)
  • Purity: >97.0%(GC)
  • Packaging: 100g
  • Price: $131
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A16580
  • Product name : Propargyl bromide, 80% in toluene, stab. with MgO
  • Purity: 
  • Packaging: 250ml
  • Price: $373
  • Updated: 2021/03/22
  • Buy: Buy

3-Bromopropyne Chemical Properties,Usage,Production

  • Uses Propargyl Bromide is used in the synthesis of betulonic acid-peptide conjugates with anti-inflammatory activity. Also used in the synthesis of PEG and peptide-grafted polyesters.
  • Description Propargyl bromide is a Shock sensitive liquid, lachrymator. Supplied as an 80% solution in toluene stabilized with magnesium oxide. Alternative formulations are currently under development.
  • Chemical Properties yellow solution
  • Uses Used to make propargylic amines employed in enyne metathesis.1Employed in the propargylation of spiro ketones,2 allylic alcohols,3 and enone complexes.4
  • Synthesis Reference(s) Tetrahedron Letters, 4, p. 483, 1963 DOI: 10.1039/jr9630005127
  • General Description A colorless to light yellow liquid substance with a sharp odor. Flash point 65°F. Denser than water and insoluble in water. Vapors are heavier than air. May be irritating to skin and eyes. Used to make other chemicals. 3-Bromopropyne may decompose explosively with mild shock.
  • Air & Water Reactions Highly flammable. Insoluble in water.
  • Reactivity Profile 3-Bromopropyne is soluble in alcohol, ether, chloroform, carbon tetrachloride and carbon disulfide. 3-Bromopropyne is highly flammable and a dangerous fire risk, sensitive to shock. 3-Bromopropyne is used in organic syntheses, preparation of resins and perfume intermediates [Hawley]. There is a high danger of formation of explosive metal acetylides, when 3-Bromopropyne comes in contact with copper, high-copper alloys, mercury, or silver.
  • Hazard Flammable, dangerous fire and explosion risk. Irritant.
  • Health Hazard 3-Bromopropyne is very toxic via the oral route. If inhaled, may be harmful; contact may cause burns to skin and eyes.
  • Fire Hazard 3-Bromopropyne detonates at 428F or more; ignites by impact. Emits highly toxic fumes of bromides when heated to decomposition. Reacts vigorously with oxidizing materials. Becomes shock-sensitive when mixed with chloropicrin. Unstable, avoid heat, flame, shock, and other chemicals
  • Pharmacology Mode of action is considered to be reaction with nucleophiles in living organisms.
  • Safety Profile A poison by ingestion. A dangerous fire hazard when exposed to heat or flame. The aerated liquid may be ignited by pressure. A dangerous, extremely shock-sensitive explosive. It can detonate when heated to 22O°C, by impact (especially when mixed with chloropicrin), or when heated whde confined. May explode on contact with copper, high copper alloys, mercury, or silver. Mixtures with trichloronitromethane are shockand heat- sensitive explosives. Can react vigorously with oxidizing materials. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of Br-. See also ACETYLENE COMPOUNDS and BROMIDES.
  • Metabolism Reacts slowly with water to yield propargyl alcohol and bromide ion. It is expected to move as a typical fumigant through the soil. Probably not an ozone-depleting substance due to decomposition on absorption of ultraviolet light.
3-Bromopropyne Preparation Products And Raw materials
Raw materials
Preparation Products
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  • PROPARGYL BROMIDE: 80% IN TOLUENE, STABILIZED WITH MGO
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  • Propargyl broMide, 80 wt.% solution in toluene, stabilized with 0.3% MagnesiuM oxide
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  • Propargyl Bromide (80% in Toluene, ca. 9.2mol/L) (stabilized with MgO)
  • Propargyl bromide solution 80 wt. % in toluene, contains 0.3% magnesium oxide as stabilizer
  • Propargyl bromide solution 80 wt. % in xylene
  • PROPARGYL BROMIDE (~80% IN TOLUENE, STABLIZED WITH 0.3% MAGNESIUM OXIDE)
  • Propargyl broMide solution puruM, ~80% in toluene
  • Propargyl broMide, 80 wt.% solution in toluene, stabilized with 0.3% MagnesiuM oxide, SpcSeal
  • Propargyl bromide solution, 80 wt. % in toluene, stabilized