Chemical Properties
3-tert-butyl-4-hydroxyanisole is a colorless (white) crystals. Insoluble in water,
soluble in alcohol, soluble at 0.05% to 0.20% in most oils. Very faint phenolic type odor.
Uses
antioxidant in foods (beverages, gum, ice cream, fruits, cereals), cosmetics, topical medications, animal feeds, petroleum
products, jet fuels, rubber, plastics, paints, glues.
Uses
An antioxidant stabilizer of fats that has shown carcinogenicity at high doses
Uses
3-
tert-Butyl-4-hydroxyanisole may be used as a pharmaceutical reference standard for the determination of the analyte in plasma samples using high-resolution capillary gas chromatography-mass spectrometry with selective ion monitoring.
Application
3-tert-butyl-4-hydroxyanisole is used as an Antioxidant in foods, usually in
combination with Propyl gallate and Citric
acid for synergistic effect in Propylene glycol
solution. Combinations with BHT (Butyl hydroxy toluene) are also used.
Preparation
from iso-Butylene and pura-Methoxyphenol.
Definition
ChEBI: 3-tert-butyl-4-hydroxyanisole is an aromatic ether that is 4-methoxyphenol in which one of the hydrogens ortho- to the phenolic hydroxy group is replaced by a tert-butyl group. It has a role as an antioxidant and a human xenobiotic metabolite. It is a member of phenols and an aromatic ether.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
3-
tert-Butyl-4-hydroxyanisole is a synthetic antioxidant, widely used as a food additive to prevent oxidative deterioration of fats and oils.
Flammability and Explosibility
Non flammable
Purification Methods
Fractionally distil the phenol in vacuo, then pass it as a solution in CHCl3 through alumina, and evaporate the eluate. Recrystallise the residue from pet ether. [Beilstein 6 IV 6013.]
