Description
Neticonazole hydrochloride is a novel imidazole antifungal agent introduced for the
treatment of infections caused by Candida species. One percent neticonazole cream oncedaily
application has been reported to be effective in treating patients with tinea pedis, tinea
corporis, tinea cruris, intertrigo-type candidiasis, erosio interdigitalis and tinea versicolor.
Compared with other agents of the azole class, neticonazole has the most potent activity
against a variety of fungi, including the dermatophytes and pathogenic yeasts. It also has
activity against Gram-positive, but not Gram-negative bacteria.
Definition
ChEBI: Neticonazole hydrochloride is a hydrochloride resulting from the formal reaction of equimolar amounts of neticonazole and hydrogen chloride. An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan as an antifungal drug for the treatment of superficial skin infections. It has a role as an antifungal drug and an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is a hydrochloride, an imidazole antifungal drug and a conazole antifungal drug. It contains a neticonazole(1+).
