Silodosin

Description

Silodosin is an alpha-1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH) symptoms. It is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia; BPH), which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. It relieves the symptoms of BPH by relaxing the muscles of the bladder and prostate.

Uses

(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker[1].

References

[1] Zhao F, et, al. Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists. J Med Chem. 2016 Apr 28;59(8):3826-39. DOI:10.1021/acs.jmedchem.5b02023