1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea(R,R-TUC)

Reaction

1. Thiourea catalyst used in the enantio and diastereoselective Michael addition of malonates and ketoesters to nitroolefins.
2. Catalyst used in the enantioselective hydrazination of 1,3-dicarbonyl compounds.
3. Catalyst used for the dynamic resolution of azalactones.
4. Catalyst used in Michael-Aldol reaction of 2-mercaptobenzaldehyde with α,β-unsaturated oxazolidinone.
5. Catalyst for enantioselective synthesis of flavanones and chromanones.
6. Catalyst for the asymmetric Neber Reaction.
7. Catalyst for the three component synthesis of 2,6-diazabicyclo[2.2.2]octanones.