Description
β-Mangostin is a xanthone originally isolated from
G. mangostana with diverse biological activites. It inhibits growth of methicillin-resistant
S. aureus (MRSA) and methicillin-susceptible
S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively),
P. falciparum (IC
50 = 3 μg/ml), and
M. tuberculosis (MIC = 6.25 μg/ml). β-Mangostin inhibits fatty acid synthase (FASN) with an IC
50 value of 24.83 μM. It induces cell cycle arrest at the G
2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells. β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E
2 (PGE
2; ) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.
Uses
β-Mangostin is isolated from the stem bark of Garcinia mangostana L. which shows significant cytotoxicities and anti-inflammatory activities against the LPS-induced RAW cell 264.7. Also, it demonstrates anti-metastatic activity against human hepatocellular carcinoma (HCC) cells, which may act as a promising therapeutic agent for the treatment of HCC.
