Chemical Properties
White, crystalline solid; odorless; bitter
taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water.
Originator
Tromexan,Geigy,US,1950
Uses
Medicine (anticoagulant).
Definition
A synthetic derivative of bishydroxycoumarin.
Manufacturing Process
7 g of benzotetronic acid are dissolved in 750 cc of water at boiling
temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl
alcoholate are added. After a short while the liquid becomes turbid and
gradually a white deposit is separated. The deposit is filtrated and dried in
vacuo. The melting point is 172°C to 174°C; after recrystallization from
methyl alcohol 153°C to 154°C.
The crude product is dissolved in sodium lye, filtrated by means of animal
charcoal precipitated by means of hydrochloric acid, and recrystallized from
methyl alcohol. The melting point is 153°C to 154°C.
Therapeutic Function
Anticoagulant
Synthesis
Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy-
3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine,
but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde.
