Description
2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides. [Matreya, LLC. Catalog No. 1708]
Uses
Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.
References
[1] RAMONA JENSKE . Impact of free hydroxylated and methyl-branched fatty acids on the organization of lipid membranes[J]. Chemistry and Physics of Lipids, 2008, 154 1: Pages 26-32. DOI:
10.1016/j.chemphyslip.2008.03.010[2] KISHORE LINGAM GANGADHARA . Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents[J]. Bioorganic & Medicinal Chemistry Letters, 2014, 24 3: Pages 817-820. DOI:
10.1016/j.bmcl.2013.12.093
