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Methylene Blue

Methylene Blue Structure
Methylene Blue
  • CAS No.61-73-4
  • Chemical Name:Methylene Blue
  • CBNumber:CB2748858
  • Molecular Formula:C16H18ClN3S
  • Formula Weight:319.85
  • MOL File:61-73-4.mol
Methylene Blue Property
  • Melting point: :190 °C (dec.)(lit.)
  • Density  :1.0 g/mL at 20 °C
  • refractive index  :n20/D1.347
  • Flash point: :45 °C
  • storage temp.  :Store at RT
  • solubility  :Soluble in water, ethanol, ethylene glycol, methyl cellosolve
  • form  :Liquid
  • pka :2.6, 11.2(at 25℃)
  • Colour Index  :52015
  • color  :Green
  • Specific Gravity :0.98
  • Odor :Odorless
  • Water Solubility  :40 g/L (20 ºC)
  • λmax :661 nm
  • Merck  :14,6060
  • BRN  :3641570
  • Biological Applications :Detecting microorganisms; treating diabetic retinopathy,macular degeneration,malignant uveal melanomas,erysipelas,hidradenitis suppurativa,inflammation,skin diseases
  • FDA 21 CFR :310.545
  • Indirect Additives used in Food Contact Substances :METHYLENE BLUE
  • EWG's Food Scores :1-4
  • FDA UNII :T42P99266K
  • NIST Chemistry Reference :Methylene blue(61-73-4)
  • EPA Substance Registry System :Methylene blue (61-73-4)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H226
  • Precautionary statements P370+P378-P403+P235
Methylene Blue Price More Price(17)
  • Brand: Sigma-Aldrich
  • Product number: 03978
  • Product name : Methylene Blue solution
  • Purity: 
  • Packaging: 250ml
  • Price: $41.9
  • Updated: 2020/08/18
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  • Brand: Sigma-Aldrich
  • Product number: 457250
  • Product name : Methylene Blue - CAS 61-73-4 - Calbiochem
  • Purity: Inhibitor of soluble guanylate cyclase.
  • Packaging: 1 g
  • Price: $42.36
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: M9140
  • Product name : Methylene blue
  • Purity: certified by the Biological Stain Commission
  • Packaging: 25 g
  • Price: $80.5
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 284-M
  • Product name : Methylene Blue solution alkaline according to Loeffler
  • Purity: 
  • Packaging: 12
  • Price: $89
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Y0001744
  • Product name : Methylthioninium for system suitability
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy

Methylene Blue Chemical Properties,Usage,Production

  • Chemical Properties green fine crystalline powder
  • Uses A useful inhibitor of cGMP-mediated processes and a useful stain
  • Definition ChEBI: An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.
  • Hazard Toxic by ingestion.
  • Biological Activity Biological stain and redox indicator. Inhibits tau filament formation (IC 50 = 1.9 μ M). Also inhibits soluble guanylyl cyclase.
  • Clinical Use Methylene blue is 3,7-bis(dimethylamino)-phenazathioniumchloride (Urised). The compound occurs as a dark greencrystalline powder with a metallic appearance that is solublein water (1:25) and alcohol (1:65).
    Methylene blue has weak antiseptic properties that makeit useful for the treatment of cystitis and urethritis. The actionof methylene blue is considered to be bacteriostatic.The compound colors the urine and stool blue green.
  • Safety Profile Poison by ingestion,intraperitoneal, intravenous, and subcutaneous routes.Human systemic effects: cyanosis, blood changes.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits verytoxic fumes of NOx, SOx, and
  • Veterinary Drugs and Treatments Methylene blue is used primarily for treating methemoglobinemia secondary to oxidative agents (nitrates, chlorates) in ruminants. It is also employed occasionally as adjunctive or alternative therapy for cyanide toxicity.
    Intra-operative methylene blue is also being used to preferentially stain islet-cell tumors of the pancreas in dogs in order to aid in their surgical removal or in determining the animal’s prognosis.
  • Purification Methods Crystallise the chloride from 0.1M 664 2HCl (16mL/g), the crystals are separated by centrifugation, washed with chilled EtOH and diethyl ether, and dried under vacuum. Crystallise it from 50% aqueous EtOH, wash it with absolute EtOH, and dry it at 50-55o for 24hours. It has also been crystallised from *benzene/MeOH (3:1). It has been salted out with NaCl from a commercial concentrated aqueous solution, then crystallised from water, and dried at 100o in an oven for 8-10hours. [Beilstein 27 III/IV 5152.]
Methylene Blue Preparation Products And Raw materials
Raw materials
Preparation Products
Global(235)Suppliers
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