Dimethyl acetylenedicarboxylate - Reaction / Application on Synthetic Work
Dimethyl acetylenedicarboxylate (DMAD) is a useful precursor in organic synthesis. DMAD can undergo Cu(I)-catalyzed radical addition with acetophenones to yield furan derivatives.
Nov 20，2019
The Uses of Dimethyl acetylenedicarboxylate
Dimethyl acetylenedicarboxylate (DMAD) is an electron-deficient acetylenic compound having two reactive ester groups. It is a privileged and advantaged molecule, which participates easily and practically in heterocyclization. Due to the presence of two ester electron-withdrawing group, DMAD easily undergoes Michael addition, which is followed by heterocyclization to afford versatile heterocyclic compounds with different ring sizes. DMAD carries out Diels–Alder reactions under mild conditions to give heterocycles, which could not be easily synthesized via conventional heterocyclizations.
Aug 27，2019
