Application in Rheumatic Arthritis
Penicillamine onset may be seen in 1 to 3 months, and most responses occur within 6 months. Early adverse effects include skin rash, metallic taste, hypogeusia, stomatitis, anorexia, nausea, vomiting, and dyspepsia. Glomerulonephritis may occur, which manifests as proteinuria and hematuria. Penicillamine is usually reserved for patients who are resistant to other therapies because of the rare but potentially serious induction of autoimmune diseases (e.g., Goodpasture’s syndrome, myasthenia gravis).
Chemical Properties
white to almost white crystalline powder
Uses
antirheumatic,
chelating agent (copper),
Wilson's desease treatment
Uses
DL-Penicillamine is a penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
Definition
ChEBI: An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Safety Profile
Poison by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
