Chemical Properties
White crystalline powder
Uses
Reactant for synthesis of:
Diazo-transfer reagents
Reagent for synthesis of:
Cannabinoid CB1 receptor agonists
Selective small-molecule melanocortin-4 receptor agonists
Imidazoles as selective cannabinoid CB2 receptor antagonists
Cyclic alpha-peptoids
Cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor
General Description
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate is a reagent used for the coupling and esterification of sterically hindered amino acids.
[1]
reaction suitability
reaction type: Coupling Reactions
Solubility in organics
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate is soluble in DMF; partially soluble in H2O, MeOH, EtOAc, CH2Cl2, and CHCl3.
storage
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate (CIP) can be stored refrigerated for at least 5 years without loss of reactivity. CIP is an irritant and should be used in a fumehood, when possible.
References
1. (a) Humphery, J. M.; Chamberlin, R., Chem. Rev. 1997, 97, 2243. (b) Albericio, F.; Carpino, L. A., Methods Enzymol. 1997, 289, 104
