Description
Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found in
Nalanthamala and has potassium channel inhibitory and antiviral activities. It inhibits binding of the potassium channel inhibitor charybdotoxin to Jurkat cell membranes (IC
50 = 3 μM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (K
v) channel K
v1.3 (IC
50 = 3.9 μM). Nalanthalide depolarizes T cells
in vitro with an EC
50 value of 500 nM. It also inhibits HIV-1 integrase activity with IC
50 values of 10 and 25 μM in coupled and strand transfer assays, respectively.
Definition
ChEBI: Nalanthalide is a pyranone diterpenoid isolated from Nalanthamala and Chaunopycnis alba and has been shown to be a blocker of the voltage-gated potassium channel Kv1.3 It has a role as a metabolite and a potassium channel blocker. It is a diterpenoid, an enol ether, an ortho-fused bicyclic hydrocarbon, an acetate ester, a member of 4-pyranones and a ketene acetal.
