ABT 894

ABT 894 is more potent than ABT-089 at both receptor subtypes, with K _i values of 1.9 nM for ¹²⁵ I-α-conotoxinMII binding and of 1.3 nM for ¹²⁵ I-epibatidine binding.

ABT 894 (0.001 to 0.10 mg/kg, po) produces significant reductions in LIDs compared to vehicle monkey. It does not decrease LIDs in monkeys with severe nigrostriatal damage.