(R)-7,7Bis[(4S)-(phenyl)oxazol-2-yl)]-2,23,3tetrahydro-1,1spirobiindane, min. 97% (Ra,S,S)-SpiroBOX

Reaction

1. Chiral ligand for copper-catalyzed asymmetric insertions of carbenoids into N–H bond of anilines.
2. Chiral ligand for copper-catalyzed asymmetric insertions of carbenoids into O–H bond of phenols.
3. Chiral ligand for copper-catalyzed asymmetric insertions of carbenoids into O–H bond of water.
4. Chiral ligand for copper-catalyzed asymmetric insertions of carbenoids into S–H bonds.
5. Chiral ligand for copper-catalyzed asymmetric insertions of carbenoids into Si–H bonds.
6. Chiral ligand used for enantioselective iron-catalyzed intramolecular cyclopropanations.