Rhuscholide A

Uses

Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC50 of 1.62 μM[1].

Definition

ChEBI: Rhuscholide A is a member of the class of 1-benzofurans that is 1-benzofuran-2(3H)-one substituted by a hydroxy group at position 5, a propan-2-ylidene group at position 3 and a (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl group at position 7. Isolated from Rhus chinensis, it exhibits anti-HIV activity. It has a role as a metabolite and an anti-HIV-1 agent. It is a member of 1-benzofurans, a gamma-lactone and a member of phenols.

References

[1] Gu Q, et, al. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis. Planta Med. 2007 Mar;73(3):279-82. DOI:10.1055/s-2007-967113