Description
Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2Directs differentiation of human and mouse ESCs to pancreatic cells.3 May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5
Uses
(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.
References
[1] H. FUJIKI. Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin.[J]. Philosophia (Ramat-Gan, Israel), 1984, 7 1: 866-870. DOI:
10.20772/cancersci1959.75.10\_866[2] JARI HEIKKILÄ Karl E O Å. (−)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells[J]. Biochemical and biophysical research communications, 1989, 162 3: Pages 1207-1213. DOI:
10.1016/0006-291x(89)90802-4[3] SHUIBING CHEN. A small molecule that directs differentiation of human ESCs into the pancreatic lineage[J]. Nature chemical biology, 2009, 5 4: 258-265. DOI:
10.1038/nchembio.154[4] T THATAVA. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny[J]. Gene Therapy, 2010, 18 3: 283-293. DOI:
10.1038/gt.2010.145[5] AVI RAVEH. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.[J]. Molecular Pharmacology, 2014, 86 4: 406-416. DOI:
10.1124/mol.114.092403
