Uses
Anti-inflammatory (gastrointestinal).
Definition
ChEBI: An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.
Indications
Olsalazine is approved for maintenance of remission
of ulcerative colitis, but a commonly reported
side effect is a paradoxical increase in diarrhea. The
U. S. Food and Drug Administration (FDA) has approved
balsalazide disodium (Colazal) as a treatment of
mild to moderately active ulcerative colitis.
brand name
Dipentum (UCB).
Mechanism of action
Olsalazine is approved for maintenance of remission
of ulcerative colitis, but a commonly reported
side effect is a paradoxical increase in diarrhea. The
U. S. Food and Drug Administration (FDA) has approved
balsalazide disodium (Colazal) as a treatment of
mild to moderately active ulcerative colitis.
Veterinary Drugs and Treatments
Olsalazine is used for treatment of dogs with chronic colitis that either
cannot tolerate the adverse effects associated with sulfasalazine
or the response to sulfasalazine has been ineffective.
