Synthesis
Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis.
References
[1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298
