nardosinone

Uses

Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF).

Biological Activity

Nardosinone is a main active ingredient from medical plant Nardostachys jatamansi. Nardosinone exhibits varies pharmacological effects including anti-inflammatory and anti-hypertrophic in cardiomyocytes. Nardosinone enhances activity of the nerve growth factor and promotes neural stem cells proliferation and differentiation. The molecular mechanism of its activity remains unclear.