Chemical Properties
[95%] in Benzene - 10% w/v
Uses
Please note that this product is shipped in a cooler
Uses
In solutions with inert solvents such as chloroform, carbon tetrachloride, benzene and ether for the phosphorylation of nucleosides and amino acids.
Uses
Dibenzyl Phosphorochloridate is used as a phosphorylating reagent for alcohols, phenols, amines, and amides; removal of benzyl groups from the
products affords phosphoric monoesters and monoamides respectively.
Preparation
Oxidative halogenation of dibenzyl phosphite using Cl2 or N-chlorosuccinimide
yields dibenzyl phosphorochloridate (BPC). The reaction of dibenzyl hydrogen phosphate with PCl5 is also
used. The latter procedure is employed for the preparation of p-substituted benzyl derivatives such as p-nitrobenzyl and p-chlorobenzyl. These substituted benzyl phosphates are crystalline and more stable than
BPC but have reactivities similar to the parent chloridate.
storage
Dibenzyl phosphorochloridate may be stored in the cold but preferably
prepared just prior to use. Distillation of the chloridate may cause violent decomposition.
