Chemical Properties
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Uses
1-Bromo-1-propene upon
n-BuLi treatment generates the propynyllithium anion,
in situ, which later undergoes nucleophilic addition reactions. Some of its other applications are:
- Synthesis of organic reagents such as methyl but-2-ynoate and 1-iodopropyne.
- Preparation o f intermediates in the total synthesis of (+)-aphanamol I and skyllamycins A-C.
- Synthesis of allylated pyrazoles, aryl alkynyl sulfides and allenamides.
Uses
1-Propenyl bromide is a useful building block, especially when a 3 carbon addition is required, such as its use in the synthesis of the pharmaceutical spilanthol.
Synthesis Reference(s)
The Journal of Organic Chemistry, 56, p. 4066, 1991
DOI: 10.1021/jo00012a053
