Description
An amorphous alkaloid, leonurine has been obtained from the leaves of Leonurus
sibiricus L. and is characterized as the crystalline hydrochloride hydra te, m.p.
19l-4°C. Hydrolysis yields syringic acid and Q-hydroxybutylguanidine. The
total synthesis of the alkaloid has been achieved, confirming the above structure.
Uses
Leonurine Hydrochloride is an alkaloid plant extract used in the treatment of uterine disorders. Used in the modification of uterine contractions in rats.
Uses
Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus. A natural product with antioxidant, anti-inflammatory and cardioprotective properties for the treatment of wild variety of conditions including stroke, cerebral thrombosis and cardiovascular diseases.
Definition
ChEBI: Leonurine is a trihydroxybenzoic acid.
References
Kubota, Nakajima., Nippon Yakubusugaku Zasshi., 163 (1930)
Goto et al., Tetrahedron Lett., 545 (1962)
Total synthesis:
Kishi et al., Tetrahedron Lett., 637 (1968)
