Dimethyl adipate

Product NameDimethyl adipate

CAS627-93-0

CBNumberCB1412954

MFC8H14O4

MW174.19

EINECS211-020-6

MDL NumberMFCD00008469

MOL File627-93-0.mol

MSDS FileSDS

Chemical Properties

Melting point	8 °C (lit.)
Boiling point	109-110 °C/14 mmHg (lit.)
Density	1.062 g/mL at 20 °C (lit.)
vapor pressure	0.2 mm Hg ( 20 °C)
refractive index	n20/D 1.428(lit.)
FEMA	4472 \| DIMETHYL ADIPATE
Flash point	225 °F
storage temp.	Store below +30°C.
solubility	<1g/l
form	Liquid
color	Clear
explosive limit	0.81-8.1%(V)
Water Solubility	Miscible with alcohols and ether. Immiscible with water.
Merck	14,162
JECFA Number	1964
BRN	1707443
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, acids, bases reducing agents.
InChIKey	UDSFAEKRVUSQDD-UHFFFAOYSA-N
CAS DataBase Reference	627-93-0(CAS DataBase Reference)
NIST Chemistry Reference	Hexanedioic acid, dimethyl ester(627-93-0)
EPA Substance Registry System	Dimethyl adipate (627-93-0)

Safety

Safety Statements	24/25
WGK Germany	1
RTECS	AV1645000
Autoignition Temperature	680 °F
TSCA	Yes
HS Code	29171290
Hazardous Substances Data	627-93-0(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 8191 mg/kg LD50 dermal Rabbit > 2250 mg/kg

Dimethyl adipate Price

Product number	Packaging	Price	Buy
Sigma-Aldrich 8.00097	250ML	$37	Buy
Sigma-Aldrich 8.00097	1L	$109	Buy
Sigma-Aldrich 186252	100g	$40	Buy
Sigma-Aldrich 186252	500g	$101	Buy
TCI Chemical A0166	25mL	$19	Buy

Dimethyl adipate Chemical Properties,Usage,Production

Description
Dimethyl adipate (DMA) is a colourless and flammable liquid. It is soluble in alcohol and ether but sparingly soluble in water. DMA is incompatible with strong oxidising agents, and on decomposition, it emits carbon monoxide, irritating and toxic fumes and gases, and carbon dioxide. DMA reacts with acids, alkalis, and strong oxidants. DMA is synthesised by the esterification of adipic acid. DMA is part of a dibasic ester (DBE) blend used as a major ingredient in several paint strippers, and the DBE blends used in paint stripping formulations contain a major portion (about 90%) of DMA. DMA is used as a chemical intermediate (polymers, agrochemicals), cellulose resins, a speciality solvent (inks, coatings, adhesives), and an emollient and can also be utilised as a paint remover and plasticiser.
Chemical Properties
Dimethyl adipate is a colorless liquid. It is a fatty acid methyl ester.
Uses
Dimethyl adipate is used in cosmetics (in emollients and skin conditioning).It is used as a plasticizer for cellulose-type resins and a finish remover.It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.
Uses
Dimethyl adipate is used in cosmetics (in emollients and skin conditioning). It acts as a cosmetic plasticizer. It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.
Production Methods
Dimethyl adipate is manufactured via esterification of adipic acid and methanol in the presence of an acid catalyst.
General Description
Colorless liquid.
Air & Water Reactions
Flammable. Hydrolyzed by strong mineral acids and strong alkalis.
Reactivity Profile
Dimethyl adipate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Health Hazard
Exposures to dimethyl adipate cause toxicity and adverse health effects in laboratory animals and humans. Workplace exposures to dimethyl adipate by inhalation, ingestion, or skin absorption cause harmful and irritation effects to users.
Health Hazard
May be harmful by inhalation, ingestion, or skin absorption. May cause irritation.
Safety Profile
Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Chemical Synthesis
Dimethyl adipate was synthesized by immobilized Candida antarctica lipase B-catalyzed esterification of adipic acid and methanol.

According to the general procedure described above, Dimethyl adipate has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 9%.
1H NMR (400.1 MHz, CDCl3): δ = 3.56 (6H, s, H1-H10), 2.23 (4H, m, H4-H7), 1.56 (4H, m, H5-H6).
13C NMR (100.5 MHz, CDCl3): δ = 173.4 (C3-C8), 51.2 (C1-C10), 33.4 (C4-C7), 24.1 (C5-C6)
https://pubmed.ncbi.nlm.nih.gov/20632329/
Carcinogenicity
In a chronic inhalation toxicity study of dimethyl adipate, groups of male and female rats were exposed to 400 mg/m³ of dimethyl adipate over a 90-day period. Focal respiratory metaplasia of the olfactory epithelium was found. These nonneoplastic lesions were minimal to mild in severity .
Precautions
During handling of dimethyl adipate, occupational workers should be careful and use self-contained breathing apparatus, rubber boots, and heavy rubber gloves and avoid prolonged period of exposures. Workers should avoid contact of dimethyl adipate with skin, eyes and nose.

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