Description
The aryl hydrocarbon receptor (AhR) is a ligand-
dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. CAY10465 is an analog of resveratrol acting as a potent and selective AhR agonist, with a K
i of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 μM.
Uses
(E)-1-[4-(Trifluoromethyl)phenyl]-2-(3,5-dichlorophenyl)ethene is a stilbene derivative of resveratrol and a selective aryl hydrocarbon receptor agonist.
References
[1] MICHAEL S DENISON Scott R N. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.[J]. Annual review of pharmacology and toxicology, 2003, 43: 309-334. DOI:
10.1146/annurev.pharmtox.43.100901.135828[2] PHILIPPE DE MEDINA. Synthesis and Biological Properties of New Stilbene Derivatives of Resveratrol as New Selective Aryl Hydrocarbon Modulators[J]. Journal of Medicinal Chemistry, 2004, 48 1: 287-291. DOI:
10.1021/jm0498194
![1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Structure](https://www.chemicalbook.com/StructureFile/ChemBookStructure9/GIF/CB1397651.gif)
