Description
PF-9366 (72882-78-1) is an allosteric inhibitor (IC50= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.
Uses
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
References
[1] CASEY L QUINLAN. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A[J]. Nature chemical biology, 2017, 13 7: 785-792. DOI:
10.1038/nchembio.2384
