Azido-dPEG4-acid

Product NameAzido-dPEG4-acid
CAS1056024-94-2
CBNumberCB13146560
MFC9H17N3O5
MW247.25
EINECS-0
MDL NumberMFCD23726617
MOL File1056024-94-2.mol
MSDS FileSDS

Chemical Properties

solubility

DMSO : 100 mg/mL (404.45 mM; Need ultrasonic)

Safety

HS Code

2918999090

Azido-dPEG4-acid Price

Product number	Packaging	Price	Product description	Buy
TRC A965575	50mg	$155	Azido-peg3Acid	Buy
TRC A965575	100mg	$240	Azido-peg3Acid	Buy
Apolloscientific BIPG1105	500mg	$378	Azido-PEG3-acid	Buy
AK Scientific AMTGC715	250mg	$160	3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoicacid	Buy
BroadPharm BP-21583	250mg	$160	Azido-PEG3-acid 98%	Buy

Azido-dPEG4-acid Chemical Properties,Usage,Production

Description

Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Definition

ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound.

Biological Activity

Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

PEGs	Non-cleavable

Preparation Products And Raw materials

Azido-dPEG4-acid Suppliers

Global(66)Suppliers

Region

CHINA 58 India 1 United States 7

Clear All Done

Supplier	Tel	Email	Country	ProdList	Advantage
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Wuhan Borenpharm Co., Ltd	027-65563561 18717150066	3207347307@qq.com	CHINA	1238	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6710	58
Shaanxi Youbang Biopharma Technology Co.,Ltd.	+86-0913-7167565 +8618754046789	316745545@qq.com	China	86	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3149	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58