2,3-DCPE

Description

2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC₅₀s = 0.89-2.69 μM) more effectively than in normal human fibroblasts (IC₅₀ = 12.6 μM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction. 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.

Uses

2,3-DCPE is a compound that induces both upregulation and S-phase arrest in p21. Used as an anti-cancer treatment as it induces apoptosis.

storage

Desiccate at -20°C