XPhos Pd G1

Reaction

1. Catalyst for cross-coupling reactions of electron-deficient anilines with aryl chlorides.
2. Catalyst for rapid C-N bond-forming process at low catalyst loading.
3. Catalyst for C-N cross-coupling reactions, at or below room temperature.
4. Catalyst for the synthesis of tetracyclic indoles via intermolecular α-arylation of ketones.
5. Catalyst for the cross-coupling of benzyl chlorides with cyclopropanol-derived ketone homoenolates

Uses

XPhos Pd G1 is used as androgen receptor modulator for treatment of disorders including prostate cancer.

Uses

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst used for:

• Amination / cyclization reactions
• C-N bond-forming reactions via packed-bed microreactors
• Boration of aryl chlorides
• Arylation of oxazole
• Cross-coupling reactions

Preparation

XPhos Pd G1 is an insoluble solid that can be prepared by cross-coupling reactions of imidazole derivatives with dioxane. 

General Description

Material may contain up to 5% pentane

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

Physiological effects

XPhos Pd G1 has been shown to have anti-infectious properties against bacteria and viruses including influenza A, respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), and hepatitis B. It also has metabolic effects on the body by reducing levels of pyridine compounds and increasing pyrazolyl concentrations in the blood stream.