Description
Diethyl isocyanoMethylphosphonate is a reagent for the elongation of aldehydes and ketones with a one-carbon unit; connective reagent; N,P-acetals; reagent for the conversion of nitroalkenes into 2-pyrrolephosphonates.
Chemical Properties
Clear colorless to yellow liquid
Uses
Reactant for:
- Copper-catalyzed cycloaddition reactions
- Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase
- Synthesis of sterol analogs as antifungal agents against plant pathogens
- Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions
- The Passerini reaction
reaction suitability
reaction type: C-C Bond Formation
Synthesis
Diethyl isocyanoMethylphosphonate is prepared by dehydration of N-(diethoxyphosphorylmethyl)formamide.
storage
Stored for long periods of time at 0 °C or below
