Description
5(S),15(S)-
DiHETE is synthesized by 15-
LO from 5(S)-
HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB
4. 5(S),15(S)-
DiHETE is chemotactic for eosinophils with an ED
50 value of 0.3 μM.
Uses
5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin.
Uses
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.
Definition
ChEBI: 5(S),15(S)-DiHETE is a DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. It has a role as a rat metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 5(S),15(S)-DiHETE(1-).
References
[1] GREEN F A. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism[J]. Lipids, 1990, 25 10: 618-623. DOI:
10.1007/bf02536012[2] JOSEPH T. O’FLAHERTY Michael J T. Effect of 15-lipoxygenase-derived arachidonate metabolites on human neutrophil degranulation[J]. Prostaglandins, leukotrienes, and medicine, 1985, 17 2: Pages 199-212. DOI:
10.1016/0262-1746(85)90107-6[3] E. MORITA E C J Schrder. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid.[J]. Journal of immunology, 1990, 144 5 1: 1893-1900. DOI:
10.4049/jimmunol.144.5.1893
