Description
5(S),15(S)-
DiHETE is synthesized by 15-
LO from 5(S)-
HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB
4. 5(S),15(S)-
DiHETE is chemotactic for eosinophils with an ED
50 value of 0.3 μM.
Uses
5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin.
Uses
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.
Definition
ChEBI: 5(S),15(S)-DiHETE is a DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. It has a role as a rat metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 5(S),15(S)-DiHETE(1-).
