Description
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside is derived from the root of Polygonaceae species Polygonum multiflorum and is a stilbene compound. It has antioxidant, hypotensive, anti-aging, anti-inflammatory, hypolipidemic, cardioprotective and neuroprotective effects. It can also inhibit the formation of 5-HETE, HHT and thromboxane B2.
Uses
2,3,4'',5-Tetrahydroxystilbene 2-O-Glucoside is a scavenging agent, that attenuates free radicals and upregulate antioxidant?/detoxifying enzymes to protect against oxidative damage. It also protects UB/OC-2 cells from H2O2-induced autophagy and apoptosis in vitro.
Definition
ChEBI: (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. It has a role as an antioxidant, a cyclooxygenase 2 inhibitor, an anti-inflammatory agent, a cardioprotective agent, a platelet aggregation inhibitor and an apoptosis inhibitor. It is a stilbenoid, a beta-D-glucoside and a member of resorcinols.
General Description
2,3,5,4′ -Tetrahydroxystilbene-2-
O-beta-glucoside (THSG) is a
Polygoni Multiflori based polyphenol.
Biochem/physiol Actions
2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside induces the expression and enhances the activity of EPO. The compound stimulates mitochondrial biogenesis, and expression of hemoglobin in non-hematopoietic cells. 2,3,5,4′-Tetrahydroxystilbene 2-O-β-D-glucoside has demonstrated protective effects in cardiovascular disease and ischemia models.
Physiological effects
Stilbene glycosides have the functions of brain protection, free radical scavenging, blood lipid lowering, liver protection, anti-tumor, vasodilation, and inhibition of atherosclerosis.
