N,N'-bis(salicylideneamino)ethane-manganese(II)

Uses

[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties.

Biochem/physiol Actions

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.