Description
Palitantin is a fungal metabolite originally isolated from
P. palitans. It inhibits HIV-1 integrase with IC
50 values of 350 and 268 μM for 3’-processing and strand transfer activity, respectively. Palitantin has been used as a standard for dereplication of natural products.
References
[1] J H BIRKINSHAW H R. Studies in the biochemistry of micro-organisms: Palitantin, C(14)H(22)O(4), a hitherto undescribed metabolic product of Penicillium palitans Westling.[J]. Biochemical Journal, 1936, 30 5: 801-808. DOI:
10.1042/bj0300801[2] HUIXIAO HONG. Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching[J]. Journal of Medicinal Chemistry, 1997, 40 6: 930-936. DOI:
10.1021/jm960754h[3] KRISTIAN F. NIELSEN*. Dereplication of Microbial Natural Products by LC-DAD-TOFMS[J]. Journal of Natural Products , 2011, 74 11: 2338-2348. DOI:
10.1021/np200254t
