SULCONAZOLE
- Product NameSULCONAZOLE
- CAS61318-90-9
- CBNumberCB1102530
- MFC18H15Cl3N2S
- MW397.75
- MDL NumberMFCD00865585
- MOL File61318-90-9.mol
- MSDS FileSDS
Chemical Properties
Boiling point | 558.2±50.0 °C(Predicted) |
Density | 1.34±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
pka | 6.55±0.12(Predicted) |
CAS DataBase Reference | 61318-90-9 |
FDA UNII | 5D9HAA5Q5S |
ATC code | D01AC09 |
SULCONAZOLE Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
American Custom Chemicals Corporation API0004256 | 100MG | $885.31 | SULCONAZOLE 95.00% |
Buy |
American Custom Chemicals Corporation API0004256 | 500MG | $1091.48 | SULCONAZOLE 95.00% |
Buy |
American Custom Chemicals Corporation API0004256 | 1G | $1575 | SULCONAZOLE 95.00% |
Buy |
AHH MT-58832 | 0.5g | $380 | Sulconazole 98% |
Buy |
Alichem 61318909 | 1g | $653.12 | 1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole |
Buy |
SULCONAZOLE Chemical Properties,Usage,Production
Uses
Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.Definition
ChEBI: A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts.Indications
Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.Side effects
Local irritations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.Synthesis
Sulconazole, 1-[2,4-dichloro-|?-[(4-chlorobenzyl)thio]phenethyl]-imidazole (35.2.9), is an analog of exonazole. It differs in the replacement of the etheral oxygen bridge (which connects the 4-chlorobenzyl part of the molecule with phenethylimidazole) for a thioether bond. The corresponding changes in the synthesis of this drug are the replacement of the hydroxyl group in 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)-ethanol (35.2.6) with a chlorine atom using thionyl chloride, followed by a reaction of the resulting chloride with 4-chlorobenzylmercaptane to make sulconazole.Solubility in organics
1 part in 3,333 (water), 1 part in 100 (ethanol), 1 part in 130 (acetone), 1 part in 333 (chloroform), 1 part in 2000 (dioxan), 1 part in 71 (methanol), 1 part in 286(chloromethane), 1 part in 10 (pyridine), 1 part in 2000 (toluene).Preparation Products And Raw materials
SULCONAZOLE Suppliers
Global(48)Suppliers
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+1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
Related articles
Pharmacodynamics of Sulconazole
Sulconazole has a broad spectrum of antifungal activity in vitro and has been shown to be an effective topical antifungal agent for the management of superficial fungal infections of the skin, particularly dermatophytoses and tinea versicol
Mar 30,2022
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