Description
Salbutamol-d
9 is intended for use as an internal standard for the quantification of salbutamol (Item Nos.
21003 |
23991) by GC- or LC-MS. Salbutamol is an agonist of the β
2-adrenergic receptor (β
2-AR; K
d = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for β
2-ARs over β
1- and β
3-ARs (K
ds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs. It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC
50 = 39.7 μg). Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Chemical Properties
Off-White to Pale Yellow Solid
Uses
A labeled -adrenoceptor agonist
Uses
RAC ALBUTEROL-D9 is a labelled β2-adrenoceptor agonist,it is intended for use as an internal standard for the quantification of Albuterol by GC- or LC-mass spectrometry.
Uses
A labelled β2-adrenoceptor agonist. Bronchodilator; tocolytic.
References
[1] CHRISTOPHER KERN. Synthesis and Pharmacological Characterization of β2-Adrenergic Agonist Enantiomers: Zilpaterol[J]. Journal of Medicinal Chemistry, 2009, 52 6: 1773-1777. DOI:
10.1021/jm801211c[2] BAKER J G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors[J]. British Journal of Pharmacology, 2009, 144 3: 317-322. DOI:
10.1038/sj.bjp.0706048[3] VALERIE A. CULLUM. Salbutamol: a new, selective β-adrenoceptive receptor stimulant[J]. British Journal of Pharmacology, 1969, 35 1: 141-151. DOI:
10.1111/j.1476-5381.1969.tb07975.x[4] M.G. ARROYO. Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction[J]. Journal of Veterinary Internal Medicine, 2016, 30 4: 1333-1337. DOI:
10.1111/jvim.14320
