7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Chemical Properties

White or almost white, crystalline powder

Originator

Rocornal,Mochida,Japan,1978

Uses

Vasodilator;PDGF antagonist

Definition

ChEBI: Trapidil is a member of triazolopyrimidines.

Manufacturing Process

8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.

Therapeutic Function

Coronary vasodilator

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.