K-604 dihydrochloride

Biological Activity

K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with IC50 of 0.45±0.06 μM.

in vivo

Using F1B hamsters, an animal model susceptible to diet-induced hyperlipidemia and atherosclerosis, the effects of K-604 dihydrochloride on aortic lesion areas and plasma cholesterol levels are assessed.

target

ACAT-1 < span> 0.45 μM (IC 50 )

ACAT-2 102.85 μM (IC 50 )