Description
trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from
Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC
50s =3.6, 10.2, 16.1, 54, and 2.5 μM, respectively).
trans-trismethoxy Resveratrol (15 μM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 μM.
Chemical Properties
Pale Yellow Oil
Uses
Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health. Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.
Uses
A resveratrol analog with a variety of pharmacology action, including
inst microtubule-destabilization
Uses
A resveratrol analog with a variety of pharmacology action, including anti-cancer properties, anti-allergic activity, estrogenic activity, antiangiogenic activity, and vascular-targeting activity against microtubule-destabilization
References
[1] MICHAEL B. AUSTIN Joseph P N. The Chalcone Synthase Superfamily of Type III Polyketide Synthases[J]. ChemInform, 2003, 34 17. DOI:
10.1002/chin.200317284[2] FAHAD S ALDAWSARI Carlos A V M. 3,4’,5-trans-Trimethoxystilbene; a natural analogue of resveratrol with enhanced anticancer potency.[J]. Investigational New Drugs, 2015, 33 3: 775-786. DOI:
10.1007/s10637-015-0222-x[3] JUSTIN J. HEYNEKAMP. Substituted trans-Stilbenes, Including Analogues of the Natural Product Resveratrol, Inhibit the Human Tumor Necrosis Factor Alpha-Induced Activation of Transcription Factor Nuclear Factor KappaB[J]. Journal of Medicinal Chemistry, 2006, 49 24: 7182-7189. DOI:
10.1021/jm060630x[4] MIRELLA BELLERI. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4’-trimethoxystilbene.[J]. Molecular Pharmacology, 2005, 67 5: 1451-1459. DOI:
10.1124/mol.104.009043
