Description Mechanism of Action Precautions
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Aceclofenac

Description Mechanism of Action Precautions
Aceclofenac Structure
Aceclofenac
  • CAS No.89796-99-6
  • Chemical Name:Aceclofenac
  • CBNumber:CB0402570
  • Molecular Formula:C16H13Cl2NO4
  • Formula Weight:354.18
  • MOL File:89796-99-6.mol
Aceclofenac Property
Safety
  • Hazard Codes  :T,N
  • Risk Statements  :25-36-50/53
  • Safety Statements  :26-45-60-61
  • RIDADR  :UN 2811 6.1 / PGIII
  • WGK Germany  :3
  • HazardClass  :6.1
  • PackingGroup  :III
  • HS Code  :29224999
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H400-H301-H319-H410
  • Precautionary statements P264-P270-P301+P310+P330-P405-P280i-P301+P310a-P321-P501a-P305+P351+P338-P273-P301+P310-P501
Aceclofenac Price More Price(35)
  • Brand: Sigma-Aldrich
  • Product number: A8861
  • Product name : Aceclofenac
  • Purity: ≥98% (HPLC)
  • Packaging: 10mg
  • Price: $76.6
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: A8861
  • Product name : Aceclofenac
  • Purity: ≥98% (HPLC)
  • Packaging: 50mg
  • Price: $296
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: A2484
  • Product name : Aceclofenac
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 1g
  • Price: $10
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: A2484
  • Product name : Aceclofenac
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 5g
  • Price: $27
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J60355
  • Product name : Aceclofenac
  • Purity: 99%
  • Packaging: 1g
  • Price: $16.7
  • Updated: 2021/12/16
  • Buy: Buy

Aceclofenac Chemical Properties,Usage,Production

  • Description Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
    The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.
  • Mechanism of Action Aceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.
  • Precautions Before taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.
  • Description Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.
  • Description Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) and a derivative of diclofenac (Item Nos. 22983 | 70680). Aceclofenac inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) by 25 and 30%, respectively, in cell-free assays when used at concentrations of 10 and 100 μM, respectively. It selectively inhibits COX-2 in isolated whole blood (IC50s = 0.8 and >100 μM for COX-2 and COX-1, respectively) and inhibits the production of PGE2 in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM). Aceclofenac reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, when used at a concentration of 30 μM. Aceclofenac inhibits carrageenan-induced paw edema (ED50 = 3.6 mg/kg) and abscess formation (ED30 = 1.1 mg/kg) in rats. It also inhibits an increase in joint diameter in a rat model of arthritis induced by complete Freund’s adjuvant (CFA).
  • Chemical Properties White Crystalline Solid
  • Originator Prodes (Prodesfarma) (Spain)
  • Uses A non-steroidal, anti-inflammatory drug (NSAID) with potent inhibitory activity in several models of inflammation
  • Uses Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.
  • Definition ChEBI: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
  • Manufacturing Process 50 g of sodium 2-[(2,6-dichlorphenyl)amino]phenylacetate were dissolved in 300 ml of N,N-dimethylformamide under heating to 50°C, and 44.22 g of benzyl bromoacetate were added thereto. Under these condition stirring was continued for 9 hours. Upon completion of the reaction, the solvent was removed at reduced pressure, and the sodium salt were precipitated with addition of 400 ml of ether. The solution was then filtered and the ether phase was washed twice time with 100 ml of hexane. The resulting product was crystallized from the hexane/ether and then from acetone/chloroform (1:9) thus obtaining 44.1 g (61%) of benzyl 2-[(2,6- dichlorphenyl)amino]phenylacetoxyacetate in the form of white crystals having a melting point of 67-69°C.
    45.28 g of benzyl 2-[(2,6-dichlorphenyl)amino]phenylacetoxyacetate were dissolved in 1500 ml of ethyl acetate, and the resulting solution was mixed with 7 g of Pd/C 10% and then hydrogen ted at atmospheric pressure for 14 hours. The solution was filtered, concentrated and crystallized; thereby obtaining 23.51 g (65%) of 2-[(2,6-dichlorphenyl)amino]phenylacetoxyacetic acid; melting point 149-150°C.
  • brand name Airtal; Gerbin
  • Therapeutic Function Analgesic, Antiinflammatory
Aceclofenac Preparation Products And Raw materials
Raw materials
Preparation Products
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89796-99-6, AceclofenacRelated Search:
  • ACECLOFENAC
  • ACECLOFENAC-D2
  • Airtal
  • Falcol
  • Gerbin
  • Glycolic Acid [o-(2,6-Dichloroanilino)phenyl]acetate Ester
  • PR-82/3
  • Preservex
  • o-(2,6-Dichloranilino)-phenyl-acetoxy-essigsure
  • Biofenac
  • Tresquim
  • 2-[(2,6-Dichlorophenyl)amino]phenylacetoxyacetic acid
  • [[[2-[(2,6-Dichlorophenyl)amino]phenyl]acetyl]oxy]acetic acid
  • Aceclofenac, 98%, NSAID. Cyclooxygenase inhibitor
  • ACECLOFENAC, IMP. E (EP): ETHYL 2-[(2-{2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL}ACETYL)OXY]ACETATE (ETHYL ESTER OF ACECLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMP. B (EP): METHYL 2-{2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL}ACETATE(METHYL ESTER OF DICLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMP. C (EP): ETHYL 2-[2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE (ETHYL ESTER OF DICLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMP. D (EP): METHYL 2-[(2-{2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL}ACETYL)OXY]ACETATE (METHYL ESTER OF ACECLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMP. IMP. G (EP):2[[2-[[2-[2-[(2,6-DICHLORPHENYL)-AMINO]PHENYL]ACETYL]OXY]ACETYL]OXY]ACETIC ACID (ACETIC ACECLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMP. I (EP):1-(2,6-DICHLOROPHENYL)INDOLIN-2-ONE MM(CRM STANDARD)
  • ACECLOFENAC REFERENCE SPECTRUM EPY(CRM STANDARD)
  • ACECLOFENAC, IMPURITY FBENZYL[[[2-[(2,6-DICHLOROPHENYL)AMINO] PHENYL]ACETYL]OXY]ACETATE EP STANDARD
  • ACECLOFENAC, MM(CRM STANDARD)
  • ACECLOFENAC, IMP. A (EP): 2-{2-[(2,6-DICHLOROPHENYL)AMINO]-PHENYL}ACETIC ACID (DICLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMP. F (EP): BENZYL 2-[(2-{2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL}ACETYL)OXY]ACETATE(BENZYL ESTER OF ACECLOFENAC) MM(CRM STANDARD)
  • ACECLOFENAC, IMPURITY H[[[[[[[2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETYL]OXY]ACETYL]OXY] ACETYL]OXY] ACETIC ACID EP STANDARD
  • Acelofenac
  • sopropyl [2-[(2,6-Dichlorophenyl)aMino]phenyl]acetate(Isopropyl Ester of Diclofenac)
  • Aceclofenac (EP/BP)
  • [[2-[2-[(2,6-Dichlorophenyl)amino]phenyl]-1-oxoethyl]oxy]acetic acid
  • 2-(2-(2-((2,6-dichlorophenyl)aMino)phenyl)acetoxy)acetic acid
  • Aceclofenac iMpurity
  • 2-[2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl]oxyacetic acid
  • 2-((2,6-dichlorophenyl)amino)-benzeneaceticacicarboxymethylester
  • 2-((2,6-dichlorophenyl)amino)benzeneaceticacidcarboxymethylester
  • Aceclofenac, EP
  • ACECLOFENAC, IMP. C (EP): ETHYL 2-[2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE (ETHYL ESTER OF DICLOF
  • Aceclofenac-D4
  • Aceclofar
  • Zerodol
  • AceclofenacDMF API
  • 2-[2-(2,6-Dichloroanilino)phenylacetoxy]acetic Acid
  • Aceclofenac &gt
  • [[[[[[[2-[(2,6-Dichlorophenyl)amino
  • Aceclofenac for peak identification CRS
  • Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester
  • Aceclofenac USP/EP/BP
  • Aceclofenacr
  • 89796-99-6
  • 89798-99-6
  • C16H13Cl2NO4
  • Free Base API
  • API
  • AIRTAL
  • Aromatics
  • Lipid signaling
  • Active Pharmaceutical Ingredients
  • Intermediates & Fine Chemicals