Givinostat (hydrochloride)
- Product NameGivinostat (hydrochloride)
- CAS199657-29-9
- CBNumberCB03041408
- MFC24H28ClN3O4
- MW457.96
- MOL File199657-29-9.mol
- MSDS FileSDS
Chemical Properties
| storage temp. | Store at -20°C |
| solubility | DMSO:45.8(Max Conc. mg/mL);100.01(Max Conc. mM) |
| FDA UNII | Z02132R2QQ |
Givinostat (hydrochloride) Chemical Properties,Usage,Production
Biological Activity
Givinostat (ITF-2357) hydrochloride is an HDAC inhibitor, inhibits HDAC1 and HDAC3 with IC50 of 198 nM and 157 nM, respectively.in vitro
Givinostat (hydrochloride) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduces IL-1β secretion more than 70%. Givinostat suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18.in vivo
Givinostat (ITF2357) at 10 mg/kg is used as a positive control and reduces serum TNFα by 60%. Pretreatment of Givinostat (ITF-2357) starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h.
target
| hHDAC3 157 nM (IC 50 ) | hHDAC1 198 nM (IC 50 ) | hHDAC11 292 nM (IC 50 ) | hHDAC6 315 nM ( IC 50 ) | hHDAC2 325 nM (IC 50 ) | hHDAC10 340 nM (IC < sub> 50 ) | hHDAC7 524 nM (IC 50 ) | hHDAC5 532 nM (IC 50 ) | hHDAC9 541 nM (IC 50 ) | hHDAC8 854 nM (IC 50 < /sub> ) | hHDAC4 1059 nM (IC 50 ) | HD1-B 7.5 nM (IC 50 ) | HD1-A 16 nM (IC 50 ) | HD2 10 nM (IC 50 ) |
storage
Store at -20°CPreparation Products And Raw materials
Givinostat (hydrochloride) Supplier
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 | |
| +8618523575427 | sales@conier.com | China | 49732 | 58 | |
| +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 | |
| +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 | |
| support@targetmol.com | United States | 38630 | 58 | ||
| tp@aladdinsci.com | United States | 52924 | 58 | ||
| +86-512-68323658 +86-18168183658 |
sales1@artkmedchem.com | China | 39003 | 58 | |
| 571-89925085 | sales@amadischem.com | China | 131957 | 58 | |
| 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 | |
| 18149758185 18149758185 |
sales-cpd@caerulumpharma.com | China | 3466 | 58 |
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