Biological Activity
L-4-Oxalysine hydrochloride is a natural substance isolated from the culture medium of Streptomyces in China and has anticancer activity.
in vitro
L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor.
in vivo
L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma.
