Description
Dalbavancin IMpurity (Antibiotic A 40926) is a natural glycopeptide antibiotic produced by Nonomuraeasp. ATCC39727, mainly composed of PA, PB, A, B0 and B1.
Definition
The antibiotic A 40926 belongs to the teicoplanin family of glycopeptides. It consists of a complex of closely related molecules sharing a heptapeptide skeleton with a rigid scaffold determined by ether bonds between amino acids 1–3, 2–4, and 4–6, and a C-C bond between amino acids 5–7. In addition, two sugar residues and two chlorine atoms are present on the molecule. The components of the A40926 complex differ in the length of the acyl chain, with factor A1 (R = n-decyl) as the main component.
Application
Dalbavancin IMpurity is a natural glycopeptide antibiotic produced by ATCC39727, which can be used to treat bacterial infections.
Biological Activity
Dalbavancin IMpurity is the precursor of Dalbavancin, is a second-generation glycopeptide antibiotic. It inhibits Gram-positive bacteria and is very effective against Neisseria gonorrhoeae.
